WNK2 is a novel regulator of essential neuronal cation-chloride cotransporters
نویسندگان
چکیده
Jesse Rinehart*, Norma Vázquez*, Kristopher T. Kahle, Caleb A. Hodson, Aaron M. Ring, Erol E. Gulcicek, Angeliki Louvi, Norma A. Bobadilla, Gerardo Gamba¶, and Richard P. Lifton¶ Department of Genetics Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan, Mexico City, 14000, Mexico Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA Keck Biotechnology Resource Laboratory, Yale University, New Haven, CT 06510, USA
منابع مشابه
WNK2 Kinase Is a Novel Regulator of Essential Neuronal Cation-Chloride Cotransporters*
NKCC1 and KCC2, related cation-chloride cotransporters (CCC), regulate cell volume and γ-aminobutyric acid (GABA)-ergic neurotranmission by modulating the intracellular concentration of chloride [Cl(-)]. These CCCs are oppositely regulated by serine-threonine phosphorylation, which activates NKCC1 but inhibits KCC2. The kinase(s) that performs this function in the nervous system are not known w...
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Cation chloride cotransporters (CCC) play an essential role for neuronal chloride homeostasis. K(+)-Cl(-) cotransporter (KCC2), is the principal Cl(-)-extruder, whereas Na(+)-K(+)-Cl(-) cotransporter (NKCC1), is the major Cl(-)-uptake mechanism in many neurons. As a consequence, the action of the inhibitory neurotransmitters gamma-aminobutyric acid (GABA) and glycine strongly depend on the acti...
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Electroneutral cation-Cl(-) cotransporters compose a family of solute carriers in which cation (Na(+) or K(+)) movement through the plasma membrane is always accompanied by Cl(-) in a 1:1 stoichiometry. Seven well-characterized members include one gene encoding the thiazide-sensitive Na(+)-Cl(-) cotransporter, two genes encoding loop diuretic-sensitive Na(+)-K(+)-2Cl(-) cotransporters, and four...
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Electroneutral cation-chloride cotransporters are widely expressed and perform a variety of physiological roles. A novel gene family of five members, encompassing a Na+-Cl- transporter, two Na+-K+-2Cl- transporters and two K+-Cl- cotransporters, encodes these membrane proteins; homologous genes have also been identified in a prokaryote and a number of lower eukaryotes. The cotransporter protein...
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